Chronic Pain

Chronic pain in arthritis is primarily a result of inflammation and damage to the joints over an extended period. In arthritis, the immune system mistakenly attacks healthy joint tissues, leading to inflammation. This inflammation causes pain, swelling, and stiffness, contributing to the chronic nature of the condition.

The pathology involves the release of inflammatory mediators, such as cytokines, that amplify pain signals. The
ongoing damage to joint structures, including cartilage and bone, further exacerbates pain. Over time, persistent pain can also lead to changes in the nervous system, causing heightened sensitivity and chronic pain even in the absence of ongoing inflammation.

Related Articles